MCU encodes the pore conducting mitochondrial calcium currents

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MCU encodes the pore conducting mitochondrial calcium currents

Mitochondrial calcium (Ca(2+)) import is a well-described phenomenon regulating cell survival and ATP production. Of multiple pathways allowing such entry, the mitochondrial Ca(2+) uniporter is a highly Ca(2+)-selective channel complex encoded by several recently-discovered genes. However, the identity of the pore-forming subunit remains to be established, since knockdown of all the candidate u...

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ژورنال

عنوان ژورنال: eLife

سال: 2013

ISSN: 2050-084X

DOI: 10.7554/elife.00704