MCR synthesis of a tetracyclic tetrazole scaffold
نویسندگان
چکیده
منابع مشابه
Concise Synthesis of Tetrazole Macrocycle
A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo an Ugi tetrazole reaction to close the mac...
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Tetrazoles are an important class of heterocycles in a wide range of applications, such as, organocatalysis and transition metal catalysis, propellants, explosives, and perhaps most commonly, as nonclassical isosteres of carboxylic acids in medicinal chemistry. This broad utility has prompted significant effort toward tetrazole synthesis, and notable among these is that of Sharpless, in which a...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2015
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2014.12.021