MaxLink: network-based prioritization of genes tightly linked to a disease seed set

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

MaxLink: network-based prioritization of genes tightly linked to a disease seed set

UNLABELLED MaxLink, a guilt-by-association network search algorithm, has been made available as a web resource and a stand-alone version. Based on a user-supplied list of query genes, MaxLink identifies and ranks genes that are tightly linked to the query list. This functionality can be used to predict potential disease genes from an initial set of genes with known association to a disease. The...

متن کامل

Role of Centrality in Network-Based Prioritization of Disease Genes

High-throughput molecular interaction data have been used effectively to prioritize candidate genes that are linked to a disease, based on the notion that the products of genes associated with similar diseases are likely to interact with each other heavily in a network of protein-protein interactions (PPIs). An important challenge for these applications, however, is the incomplete and noisy nat...

متن کامل

Network-based gene-disease prioritization using PROPHNET

Motivation and Objectives A major goal in biomedicine is to determine the underlying genetic causes of human diseases in order to better understand them and support their prevention and treatment. However, the genetic bases of many multifactorial diseases are still unclear, and high-throughput technologies typically report hundred or thousands of genes associated to a disease of interest. In th...

متن کامل

NetworkPrioritizer: a versatile tool for network-based prioritization of candidate disease genes or other molecules

SUMMARY The prioritization of candidate disease genes is often based on integrated datasets and their network representation with genes as nodes connected by edges for biological relationships. However, the majority of prioritization methods does not allow for a straightforward integration of the user's own input data. Therefore, we developed the Cytoscape plugin NetworkPrioritizer that particu...

متن کامل

Prioritization of Suburban Accident Factors Based on Analytical Network Process

The safety management of transportation system leads to decrease in a number of traffic accidents. Identification of the primary reasons in accident incidence is the initial step in controlling the crashes. The source of accidents is divided into 3 groups; namely, human, environment and traffic. Due to the complex nature of traffic accidents, Multi-Criteria Decision-Making (MCDM) methods can be...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bioinformatics

سال: 2014

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btu344