Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens
نویسندگان
چکیده
منابع مشابه
J‐LEAPS peptide and LEAPS dendritic cell vaccines
The J-LEAPS vaccines contain a peptide from β-2-microglobulin covalently attached to disease-related peptides of 8-30 amino acids which contain a T cell epitope. The J-LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J-LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the matur...
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The J-LEAPS peptide vaccine platform allows development of vaccines that elicit antigen specific Th1 immune responses to the incorporated antigenic peptide by promoting the maturation of mouse and human precursors into type 1 dendritic cells (DC1). CD8 T cell epitopes are covalently attached to the J-immune cell binding ligand through a tri-glycine linker. J-LEAPS peptide vaccines have been tes...
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ژورنال
عنوان ژورنال: Cellular Immunology
سال: 2010
ISSN: 0008-8749
DOI: 10.1016/j.cellimm.2010.01.003