Matrix metalloproteinase 12 promotes tumor propagation in the lung
نویسندگان
چکیده
منابع مشابه
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases.
Matrix metalloproteinases (MMP) have been implicated in virtually all aspects of tumor progression. However, the recent failure of clinical trials employing synthetic MMP inhibitors in cancer chemotherapy has led us to hypothesize that some MMPs may actually serve the host in its defense against tumor progression. Here we show that mice deficient in macrophage elastase (MMP-12) develop signific...
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Matrix metalloproteinases (MMP) have been implicated in virtually all aspects of tumor progression. However, the recent failure of clinical trials employing synthetic MMP inhibitors in cancer chemotherapy has led us to hypothesize that some MMPs may actually serve the host in its defense against tumor progression. Here we show that mice deficient in macrophage elastase (MMP-12) develop signific...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2018
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2017.11.110