منابع مشابه
Matricellular proteins in cardiac adaptation and disease.
The term matricellular proteins describes a family of structurally unrelated extracellular macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue architecture, but are induced following injury and modulate cell-cell and cell-matrix interactions. When released to the matrix, matricellular proteins associate with growth factors, cytokines, and other bioactive...
متن کاملThe role of matricellular proteins in glaucoma.
Glaucoma is an optic neuropathy affecting approximately 60million people worldwide and is the second most common cause of irreversible blindness. Elevated intraocular pressure (IOP) is the main risk factor for developing glaucoma and is caused by impaired aqueous humor drainage through the trabecular meshwork (TM) and Schlemm's canal (SC). In primary open angle glaucoma (POAG), this elevation i...
متن کاملMatricellular Proteins: A Sticky Affair with Cancers
The multistep process of metastasis is a major hallmark of cancer progression involving the cointeraction and coevolution of the tumor and its microenvironment. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins, which are a family of nonstructural proteins in the extracellular matrix (ECM) that exert regulatory roles via a var...
متن کاملCCN Family: Matricellular Proteins in Cartilage and Bone Development
The extracellular matrix is the intricate scaffolding which surrounds and supports cells and helps to organize them into tissues and organs. The CCN family of matricellular proteins helps to regulate and modulate production, degradation, and remodeling of the extracellular matrix. In this chapter, we review the extracellular matrix of cartilage and bone, including an overview of chondrogenesis ...
متن کاملMatricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection
AIMS The cardiac extracellular matrix is highly involved in regulating inflammation, remodelling, and function of the heart. Whether matrix alterations relate to the degree of inflammation, fibrosis, and overall rejection in the human transplanted heart remained, until now, unknown. METHODS AND RESULTS Expression of matricellular proteins, proteoglycans, and metalloproteinases (MMPs) and thei...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2014
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2014.03.002