Mathematical modeling of immunity to malaria
نویسندگان
چکیده
منابع مشابه
Mathematical Modeling of Malaria Infection with Innate and Adaptive Immunity in Individuals and Agent-Based Communities
BACKGROUND Agent-based modeling of Plasmodium falciparum infection offers an attractive alternative to the conventional Ross-Macdonald methodology, as it allows simulation of heterogeneous communities subjected to realistic transmission (inoculation patterns). METHODOLOGY/PRINCIPAL FINDINGS We developed a new, agent based model that accounts for the essential in-host processes: parasite repli...
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Acquisition of partially protective immunity is a dominant feature of the epidemiology of malaria among exposed individuals. The processes that determine the acquisition of immunity to clinical disease and to asymptomatic carriage of malaria parasites are poorly understood, in part because of a lack of validated immunological markers of protection. Using mathematical models, we seek to better u...
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and Applied Analysis 3 host population is described by the following system of equations: dSh dt = Λ h − bβhShIv Nh − μhSh, dIh dt = bβhShIv Nh + σbβhRhIv Nh − (γh + δh + μh) Ih, dRh dt = γhIh − σbβhRhIv Nh − μhRh, dSv dt = Λ v − bβvSvIh Nh − μvSv, dIv dt = bβvSvIh Nh − μvIv. (1) The total humans host and mosquitoes vector populations Nh = Sh+Ih+Rh andNv = Sv+Iv are governed, respectively, by d...
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Mathematical models have long provided basic insights for malaria control. The recent success of the Onchocerciasis Control Program in west Africa shows that models can make great pragmatic contributions to intervention programs if the modeling is integrated into the overall program, and if the participants are clear about what models can and cannot do. This lesson can be applied to evidence-ba...
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ژورنال
عنوان ژورنال: Mathematical and Computer Modelling
سال: 1989
ISSN: 0895-7177
DOI: 10.1016/0895-7177(89)90251-3