Maternal human papillomavirus infections at mid-pregnancy and delivery in a Scandinavian mother–child cohort study

ObjectivesHuman papillomavirus (HPV) infections are common, especially during women’s reproductive years, with unclear obstetrical impact. This study aimed to identify HPV prevalence at mid-gestation and delivery, type-specific persistence from risk factors for infection persistence.MethodsIn 757 women a Scandinavian prospective mother–child cohort, was analyzed in first-void urine samples delivery. We used Seegene Anyplex II HPV28 PCR assay genotyping semi-quantifying 28 genital genotypes, including 12 high-risk HPVs (HR-HPV). Socio-demographic health data were collected through e-questionnaires.ResultsAny-HPV genotype (any of assessed) detected 38% the cohort 28% HR-HPVs 24% 16%, respectively. The most prevalent HPV16: 6% 4% Persistence Any-HPV 52%, as HR-HPV genotype-specific persistence. A short pre-conception relationship child’s father alcohol intake pregnancy increased both time points. Low viral load associated clearance delivery.ConclusionHPV higher compared low