Maternal Cigarette Smoking and Congenital Heart Defects
نویسندگان
چکیده
منابع مشابه
Maternal homocysteine and congenital heart defects.
C S i o the Editor: An estimated 80% of congenital heart defects result rom an interaction between susceptibilities in parental and fetal enomes and environmental exposures including maternal lifestyle actors (1). We and others have recently reported that women who ave congenital heart defect-affected pregnancies have alterations n folate metabolism (2). This population-based case-control study...
متن کاملMaternal smoking and congenital heart defects in the Baltimore-Washington Infant Study.
OBJECTIVE We investigated associations between maternal cigarette smoking during the first trimester and the risk of congenital heart defects (CHDs) among the infants. METHODS The Baltimore-Washington Infant Study was the first population-based case-control study of CHDs conducted in the United States. Case and control infants were enrolled during the period 1981-1989. We excluded mothers wit...
متن کاملMaternal and foetal angiogenic imbalance in congenital heart defects.
AIMS Animal models showed that angiogenesis is related to abnormal heart development. Our objectives were to ascertain whether a relationship exists between congenital heart defects (CHDs) and angiogenic/anti-angiogenic imbalance in maternal and foetal blood and study the expression of angiogenic factors in the foetal heart. METHODS AND RESULTS Maternal and cord blood placental growth factor ...
متن کاملCongenital heart defects and maternal biomarkers of oxidative stress.
BACKGROUND Women who have had pregnancies that were affected by nonsyndromic congenital heart defects have alterations in the homocysteine-methionine pathway that may indicate increased exposure to oxidative stress or reduced antioxidant defense or both. OBJECTIVE Our goal was to establish a maternal metabolic risk profile for nonsyndromic congenital heart defects that would enhance current p...
متن کاملMaternal Antihypertensive Medication Use and Congenital Heart Defects
Chronic hypertension complicates ≈2% of pregnancies, but the effects of antihypertensive medication use on the developing fetus are not well understood. There is relatively consistent evidence that maternal hypertension, regardless of its treatment, is associated with a moderately increased risk of congenital heart defects (CHDs), but the question remains as to whether early pregnancy antihyper...
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ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2015
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2015.01.013