Matching in case-control studies

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Flexible matching in case-control studies of gene-environment interactions.

Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy when genotype and exposure are either independent or associated. The authors pro...

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Nested case-control studies: should one break the matching?

In a nested case-control study, controls are selected for each case from the individuals who are at risk at the time at which the case occurs. We say that the controls are matched on study time. To adjust for possible confounding, it is common to match on other variables as well. The standard analysis of nested case-control data is based on a partial likelihood which compares the covariates of ...

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Case-Control Studies, Inference in

Classic (or ‘‘cumulative’’) case-control sampling designs do not admit inferences about quantities of interest other than risk ratios and then only by making the rare events assumption. Probabilities, risk differences, number needed to treat, and other quantities cannot be computed without knowledge of the population incidence fraction. Similarly, density (or ‘‘risk set’’) case-control sampling...

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Confounding in case control studies

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ژورنال

عنوان ژورنال: BMJ

سال: 1995

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.310.6975.329d