Matched Samples in Medical Investigations

Matched Samples in Medical Investigations.

In investigating the effects of a treatment or experience on a group of patients, it is usually necessary to observe a control group. The comparison between the two groups may be influenced by the characteristics of the subjects: for example, their sex, age, body weight, and original clinical state.. In order to secure comparability for such relevant "extraneous" factors, the controls are frequ...

Molecular investigations in medical practice

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Comparison of genetic variants in matched samples using thesaurus annotation

MOTIVATION Calling changes in DNA, e.g. as a result of somatic events in cancer, requires analysis of multiple matched sequenced samples. Events in low-mappability regions of the human genome are difficult to encode in variant call files and have been under-reported as a result. However, they can be described accurately through thesaurus annotation-a technique that links multiple genomic loci t...

Efficacy of endovascular treatment of meningiomas: evaluation with matched samples.

PURPOSE To evaluate the clinical efficacy, cost-effectiveness, and safety of presurgical devascularization of meningiomas. METHODS Matched samples of embolized and nonembolized groups of meningiomas were compared. The study variables for clinical efficacy were estimated blood loss, number of transfusions, surgical resection time, and length of hospitalization. The cost-effectiveness was evalu...

An Unconditional Exact Test For Small Samples Matched Binary Pairs