منابع مشابه
Mast Cells and Innate Lymphoid Cells: Underappreciated Players in CNS Autoimmune Demyelinating Disease
Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis, are autoimmune CNS inflammatory diseases. As a result of a breakdown in the relatively impermeable blood-brain barrier (BBB) in affected individuals, myelin-specific CD4+ and CD8+ T cells gain entry into the immune privileged CNS and initiate myelin, oligodendrocyte, and nerve axon destruction. However, desp...
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This study investigated the presence of mast cells in inflammatory aural polyps using light microscopy. The number of mast cells was increased in all examined cases and varied from 2.33 to 41.54 per mm2• The cells were located most commonly around small blood vessels. Occurrence of mast cells was not different in various types of polyps, but their density was severely increased in active in...
متن کاملThe Role of Mast Cells in Autoimmune Bullous Dermatoses
Skin mast cells (MCs), a resident immune cell type with broad regulatory capacity, play an important role in sensing danger signals as well as in the control of the local immune response. It is conceivable to expect that skin MCs regulate autoimmune response and are thus involved in autoimmune diseases in the skin, e.g., autoimmune bullous dermatoses (AIBD). Therefore, exploring the role of MCs...
متن کاملThe Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury
Bullous pemphigoid (BP) is an autoimmune and inflammatory skin disease associated with subepidermal blistering and autoantibodies directed against the hemidesmosomal components BP180 and BP230. Animal models of BP were developed by passively transferring anti-BP180 IgG into mice, which recapitulates the key features of human BP. By using these in vivo model systems, key cellular and molecular e...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2018
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-018-0080-8