Mass spectrometry of DHFR-methotrexate interaction
نویسندگان
چکیده
منابع مشابه
pharmacokinetics and bioequivalence of methotrexate in human plasma studied by liquid chromatography-mass spectrometry (lc-ms)
background methotrexate is a folic acid antagonist that has been in clinical use for five decades. its use in patients with brain tumors is primarily confined to primary central nervous system lymphoma (pcnsl), in which it is the cornerstone of chemotherapy. objectives a selective and sensitive high-performance liquid chromatography-electrospray ionization-mass spectrometry method was developed...
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Methotrexate, a structural analogue of folic acid, is one of the most frequently used chemotherapeutics, especially in haematological malignancies, various solid tumours and also inflammatory disorders. Methotrexate interferes with folate metabolism, mainly by inhibition of dihydrofolate reductase, resulting in the suppression of purine and pyrimidine precursor synthesis. The depletion of nucle...
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In rheumatoid arthritis (RA), methotrexate (MTX) is probably the most frequently used disease-modifying antirheumatic drug. It is also prescribed for other rheumatic and non-rheumatic diseases, such as juvenile RA, psoriatic arthritis, polymyositis, polymyalgia rheumatica, Horton’s arteritis, inflammatory bowel disease, etc. MTX has been reported to have negative effects on bone: the term "MTX ...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2000
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.40.s175_3