منابع مشابه
MarR family transcription factors
Figure 1. Representative MarR homologs and their mode of gene regulation. (A) Structure of MTH313 (3BPX), a MarR homolog of unknown function from Methanobacterium thermoautotrophicum, in complex with the ligand salicylate (shown in magenta). One monomer is shown in gray, the other is colored from amino to carboxyl terminus (blue to red). Note the asymmetrical ligand binding; only ligand binding...
متن کاملRegulation of Metabolic Pathways by MarR Family Transcription Factors
Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways. Such regulatory circuits ensure that anabolic pathways remain repressed unless final products are in short supply and that catabolic enzymes are not produced in absence of their substrates. The precisely tuned gene activity underlying such circuits is in the purview of transcription factors that may bind pathwa...
متن کاملStudy of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factors
MarR family proteins constitute a group of >12 000 transcriptional regulators encoded in bacterial and archaeal genomes that control gene expression in metabolism, stress responses, virulence and multi-drug resistance. There is much interest in defining the molecular mechanism by which ligand binding attenuates the DNA-binding activities of these proteins. Here, we describe how PcaV, a MarR fam...
متن کاملThe Sp-family of transcription factors.
GC-boxes and related motifs are frequently occurring DNA-elements present in many promoters and enhancers. In contrast to other elements it was generally thought that the transcription factor Sp1 is the only factor acting through these motifs. The cloning of paralogous genes of the Sp1 factor uncovered the existence of a small protein family consisting of Sp1, Sp2, Sp3 and Sp4. All four protein...
متن کاملThe IRF family of transcription factors
Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and-as a consequence-for adaptive i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2013
ISSN: 0960-9822
DOI: 10.1016/j.cub.2013.01.013