MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
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چکیده
منابع مشابه
MARKK , a Ste 20 - like kinase , activates the polarity - inducing kinase
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubuleassociated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and their disassembly. The sites are prominent in tau from Alzheimer's disease brains. We studied the activation of MARK and identi®ed the upstream kinase, MARKK, a member of the Ste20 kinase family. It ...
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Two families of protein kinases that are closely related to Ste20 in their kinase domain have been identified - the p21-activated protein kinase (Pak) and SPS1 families [1-3]. In contrast to Pak family members, SPS1 family members do not bind and are not activated by GTP-bound p21Rac and Cdc42. We recently placed a member of the SPS1 family, called Misshapen (Msn), genetically upstream of the c...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2003
ISSN: 1460-2075
DOI: 10.1093/emboj/cdg447