MARKERS OF LOW-GRADE INFLAMMATION IN PATIENTS WITH ACUTE CORONARY SYNDROME AND 2 TYPE DIABETES MELLITUS

Cardiovascular diseases cause approximately one-third of all deaths in the world, which 7.5 million are estimated to be due ischemic heart disease (IHD). Acute coronary syndromes (ACS) and sudden death most IHD-related deaths, represent 1.8 per year. Established, that patients with diabetes mellitus (DM) more likely experience ACS failure at greater risk for dying after an acute cardiac event, than without diabetes. 
 The purpose this study is evaluation leukocyte its populations count, leukocytes indices plasma level high sensitive C-reactive protein (hsCPR) hospitalized or 2 type DM. Material Methods. We observed 124 were randomized into two groups: 1st group – 93 DM; 2nd 31 30 apparently healthy persons included control group. studied count their subpopulations blood; calculated subpopulation indices: neutrophils lymphocytes ratio (NLR), monocytes (NMR), lymphocytes+monocytes (N/LMR), (NMR) admission. levels hs-CRP detected by ELISA method. Results study. significant increase white blood cells admission was our study, especially cases On contrary, counts decreased DM, versus data In patient increased parameter NMR (p<0.001). Similarly, following higher, compared parameters: NLR 3.32 times (in DM) 2.43 (p<0.001); N/LMR 2.98 2.14 LMR both groups 1.4 1.36 times, respectively (p<0.05). ACS, case DM (fig. 1): 2.1 2.59 Conclusion. characterized raised low lymphocyte association Diabetes Mellitus. Low-grade inflammation caused some ratios: NMR, N/LMR, NLR.