Marked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents
نویسندگان
چکیده
منابع مشابه
Differences in tissue angiotensin II-forming pathways by species and organs in vitro.
Angiotensin (Ang) II plays an important role in cardiovascular homeostasis, not only in the systemic circulation but also at the tissue level, and is involved in the remodeling of the heart and vasculature under pathological conditions. Although alternative Ang II-forming pathways are known to exist in various tissues, the details of such pathways remain unclear. The aim of this study was to ex...
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Reduced preload and afterload to the heart are important effects of angiotensin converting enzyme (ACE) inhibitors in the treatment of congestive heart failure. However, since angiotensin II (Ang II) directly increases the strength of myocardial contraction, suppression of Ang II formation by ACE inhibitors could potentially reduce the beneficial effects of Ang II on the failing heart. To study...
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Tonin is an enzyme of the serine protease family present in different rat tissues which releases angiotensin II (AII) directly from angiotensinogen and the tetradecapeptide renin substrate and from angiotensin I (AI). Tonin potentiates the effect of norepinephrine (NE) in the rat mesenteric artery preparation and in the aortic strips from normal and hypertensive rats. In rabbit aortic and mesen...
متن کاملSignificance of chymase-dependent angiotensin II-forming pathway in the development of vascular proliferation.
BACKGROUND Vascular tissues of humans and dogs contain chymase as an angiotensin II-forming enzyme. In this study, we investigated whether chymase-dependent angiotensin II formation plays a crucial role in the development of vascular proliferation in dog grafted veins. METHODS AND RESULTS The right external jugular vein of dogs was grafted to the ipsilateral carotid artery. As a control group...
متن کاملAlternate angiotensin II-forming pathways and their importance in physiological or physiopathological conditions.
For a long time, the renin-angiotensin-aldosterone system was considered a component of the endocrine system because angiotensin II, the main effector of this system was thought to be generated exclusively in blood, thereafter being distributed to all organs and tissues by the blood flow and becoming active on those targets that possessed the appropriate receptors for this peptide. Recently tho...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1254/jjp.61.371