MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
نویسندگان
چکیده
منابع مشابه
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cell activation in vitro. However, its role at steady state or in vivo is not clearly understood. Here, we show that MARCH1 deficiency resulted ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2013
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20122695