March 8, 1842

Sidney Farber , MD , on March 8 , 1951

Mr. Chairman, ladies and gentlemen. It is an honor, indeed, to be asked to give the Linsley R. Williams Memorial Lecture, and to participate thereby in the Laity Series of the New York Academy of Medicine. The fruitful career of Dr. Williams included contributions of great importance to the modern structure of the New York Academy of Medicine, which he served as full-time director, and also to ...

Washington University Record, March 8, 2007

Ether anaesthesia, 1842-1900.

Dmd052415 1835..1842

Drug-induced liver injury is the most frequent reason for market withdrawal of approved drugs, and is difficult to predict in animal models. Here, we analyzed transcriptomic data derived from shortand long-term cultured primary human hepatocytes (PHH) exposed to the well known human hepatotoxin chlorpromazine (CPZ). Samples were collected from five PHH cultures after short-term (1 and 3 days) a...

Dmd059352 1834..1842

Acyl glucuronides are reactive electrophilic metabolites implicated in the toxicity of carboxylic acid drugs. Valproyl 1-O-b-acyl glucuronide (VPA-G), which is a major metabolite of valproic acid (VPA), has been linked to the development of oxidative stress in VPA-treated rats. However, relatively little is known about the toxicity of in situ generated VPA-G and its contribution to VPA hepatoto...