Mapping of chromosome 3p deletions in human epithelial ovarian tumors
نویسندگان
چکیده
منابع مشابه
Homozygous deletions of human chromosome 3p in lung tumors.
Cytogenetic and loss of heterozygosity (LOH) studies have demonstrated that deletions of chromosome 3p occur at a high frequency in all forms of lung cancer. To clarify the role of 3p in lung tumorigenesis and to more precisely identify targets for positional cloning efforts, we have performed 3p deletion analyses (microsatellite and fluorescence in situ hybridization) in a series of lung cance...
متن کاملDetailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer.
Hemizygosity and homozygosity mapping studies show that many common sporadic cancers including lung, breast, kidney, cervical, ovarian, and head and neck cancer display deletions on the short arm of chromosome 3. For ovarian cancer, monochromosomal transfer suppression studies have identified three candidate regions for chromosome 3p ovarian cancer tumor suppressor genes (OCTSGs). To accurately...
متن کاملdetection of human papilloma virus type 16 in epithelial ovarian tumors samples
results out of 140 samples of oca, 70 (50%) samples were malignant cancer and 70 (50%) were benign cancer as the control group. out of 70 malignant samples 25 (36.0%) were hpv-16 positive. 2.8% of the tissue samples of the control group were positive for hpv-16. conclusions these results show a feasible role of hpv-16 in the carcinogenesis of oca. according to these results, infection with hpv ...
متن کاملdetection of human papillomavirus-16 e6-oncoprotein in epithelial ovarian tumors samples of iraqi patients
conclusions hpv type 16 was detected in only 9.67% of malignant epithelial tumors. it appears that hpv infection plays a relatively minor role in the pathogenesis of ovarian carcinomas. results out of the eight cases with functional cysts only one case (12.5%) expressed hpv. no hpv expression was seen in cases with benign and borderline tumors. out of the 31 cases with one malignant surface epi...
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We have applied restriction fragment length polymorphism analysis to a 30-member panel of primary glioma DNAs, which had been previ ously examined for loss of genetic information (C. D. James, E. Carlbom, J. P. Dumanski, M. Hansen, M. Nordenskjold, V. P. Collins, and W. K. Cavenee, Cancer Res., 48:5546-5551, 1988), to determine the frequency and sublocalization of loss of genetic information fr...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1998
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1202152