MAPping innate immunity
نویسندگان
چکیده
منابع مشابه
MAPping innate immunity.
T he capacity to mount an immune response that eliminates infection of a host by a microbial pathogen is critical for species survival and propagation. Mammals have developed complex immune systems that integrate innate responses, such as phagocytosis and the production of antimicrobial peptides after Toll-like receptor activation, along with adaptive responses, such as antibody production and ...
متن کاملInnate immunity
From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
متن کاملInnate immunity.
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infe...
متن کاملSurviving innate immunity.
In a complex environment, higher organisms face the constant threat of microbial infection. To defend against this onslaught of potential pathogens, all known members of the plant and animal kingdoms use an innate immune system. A key component of innate immunity is the production of small, cationic antimicrobial peptides (CAMPs). In mammals, recent discoveries from gene therapy and gene-knocko...
متن کاملInnate immunity and adjuvants
Innate immunity was for a long time considered to be non-specific because the major function of this system is to digest pathogens and present antigens to the cells involved in acquired immunity. However, recent studies have shown that innate immunity is not non-specific, but is instead sufficiently specific to discriminate self from pathogens through evolutionarily conserved receptors, designa...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0404890101