Mapping DNA G-quadruplex structures
نویسندگان
چکیده
منابع مشابه
FANCJ promotes DNA synthesis through G-quadruplex structures
Our genome contains many G-rich sequences, which have the propensity to fold into stable secondary DNA structures called G4 or G-quadruplex structures. These structures have been implicated in cellular processes such as gene regulation and telomere maintenance. However, G4 sequences are prone to mutations particularly upon replication stress or in the absence of specific helicases. To investiga...
متن کاملG-quadruplex unfolding in higher-order DNA structures.
G-quadruplex unfolding within a sequence of two quadruplex units was characterized by gel electrophoresis, calorimetry and spectroscopy. The obtained results suggest that the kinetics and thermodynamics of the individual quadruplex unfolding are affected by its interaction with other DNA secondary structural elements.
متن کاملQuantitative visualization of DNA G-quadruplex structures in human cells.
Four-stranded G-quadruplex nucleic acid structures are of great interest as their high thermodynamic stability under near-physiological conditions suggests that they could form in cells. Here we report the generation and application of an engineered, structure-specific antibody employed to quantitatively visualize DNA G-quadruplex structures in human cells. We show explicitly that G-quadruplex ...
متن کاملFANCJ promotes replication of G-quadruplex DNA structures
Thank you again for submitting your manuscript EMBOJ-2014-88663, "FANCJ promotes replication of G-quadruplex DNA structures." We have now received all the reports from three experts, which I am enclosing copied below. As you will see, the reviewers express some interest in the basic finding of your study, yet they also raise a number of substantive concerns, and issues with the potential to con...
متن کاملCorrigendum: Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy
Existence of G-quadruplex DNA in vivo always attract widespread interest in the field of biology and biological chemistry. We reported our findings for the existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Probes for selective G-quadruplex cross-linking was designed and synthesized that show high selectivity for G-quadrupl...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2015
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm4052