Many peptide fragments of alien antigens are homologous with host proteins, thus canalizing T-cell responses.

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Many peptide fragments of alien antigens are homologous with host proteins, thus canalizing T-cell responses.

All proteins of this world are constructed in compliance with the same rule. Accordingly, two totally unrelated proteins, on the average, share 30 identical tripeptides, two tetrapeptides, and one pentapeptide per 500 residues. With this in mind, the 221-residue-long influenza virus hemagglutinin II (IVHA-II), as a representative of alien antigens, was compared with three diverse proteins repre...

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Homologous Mouse and Human T Cell Antigens

The mouse Lyt-1, Lyt-2, and Lyt-3 lymphocyte surface antigens have been used for some years now as immunogenet ic markers whose selective expression distinguishes maturat ional and functional T cell subpopulations (1, 2). Lyt-2 and Lyt-3, for example, are selectively expressed on cytotoxic and suppressor T cells but are not found on helper T cells (3, 4). Similarly, cytotoxic depletion studies ...

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Cooperation or sabotage? Self-peptide-MHC complexes influence T-cell responses to antigens.

In their Opinion, Ge et al. [1] reviewed some recent published data on the role of self-peptide–MHC complexes in the modulation of immune responses to antigens. The authors suggest that some ‘inconsistencies’ in published findings could be attributed to potential aberrant expression of unusual MHC class II molecules (composed of Ab and Ea chains) in MHC class II-deficient mice used by Bhandoola...

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Nonsecreted bacterial proteins induce recall CD8 T cell responses but do not serve as protective antigens.

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Quantitating T cell cross-reactivity for unrelated peptide antigens.

Quantitating the frequency of T cell cross-reactivity to unrelated peptides is essential to understanding T cell responses in infectious and autoimmune diseases. Here we used 15 mouse or human CD8+ T cell clones (11 antiviral, 4 anti-self) in conjunction with a large library of defined synthetic peptides to examine nearly 30,000 TCR-peptide MHC class I interactions for cross-reactions. We ident...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1991

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.88.8.3065