Mannan Adhesins of Candida albicans: Characterization and Pathogenetic Implications.
نویسندگان
چکیده
منابع مشابه
Candida albicans adhesins: Biochemical aspects and virulence.
The recognition of host cells by the pathogenic yeast, Candida albicans, is probably an essential step in the pathogenesis of disease development. The interaction of yeast and hyphal mannoproteins with host cell receptors has been studied by a number of laboratories. C. albicans recognizes a variety of host cells as well as host cell extracellular matrix proteins. This observation is not unexpe...
متن کاملIdentification of Fibronectin Adhesins on Candida albicans
475 Abstract: The pattern of distribution of fibronectin adhesins on yeast and hyphalform Candida albicans was studied with goldlabelled fibronectin and transmission electron microscopy. The germ-tube parts of the hyphal-form cells were the major binding sites for gold-labelled fibronectin, and the attached yeast-cell parts and yeast-form cell remained unlabelled. Therefore, the walls of the ge...
متن کاملDegenerate peptide recognition by Candida albicans adhesins Als5p and Als1p.
Candida albicans and Saccharomyces cerevisiae expressing the adhesins Als5p or Als1p adhere to immobilized peptides and proteins that possess appropriate sequences of amino acids in addition to a sterically accessible peptide backbone. In an attempt to further define the nature of these targets, we surveyed the ability of yeast cells to adhere to 90- micro m-diameter polyethylene glycol beads c...
متن کاملDissociation of mannan--serum complexes and detection of Candida albicans mannan by enzyme immunoassay variations.
Candida albicans mannan was added to normal human sera and the resulting complexes were dissociated by boiling (boil) with EDTA or by alkali treatment (bead method). The mannan released was detected by "sandwich" enzyme immunoassay (EIA) or by EIA inhibition. Each EIA took 2.3 h to perform. The total time for the boil-EIA combination was 2.7 h and for the bead-EIA, 3.8 h. The temperature favora...
متن کاملCandida albicans Als adhesins have conserved amyloid-forming sequences.
The cell wall-bound Als adhesins of Candida albicans mediate both yeast-to-host tissue adherence and yeast aggregation. This aggregation is amyloid-like, with self-propagating secondary-structure changes, amyloid-characteristic dye binding, and induced birefringence (J. M. Rauceo, N. K. Gaur, K. G. Lee, J. E. Edwards, S. A. Klotz, and P. N. Lipke, Infect. Immun. 72:4948-4955, 2004). Therefore, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nippon Ishinkin Gakkai Zasshi
سال: 1995
ISSN: 0916-4804,1882-0476
DOI: 10.3314/jjmm.36.193