Manic-Depressive Illness and HLA

Genetics of manic depressive illness.

Manic depressive illness is a common and frequently debilitating familial psychiatric disorder. Efforts to understand the mechanisms of inheritance have been hindered by the complexity of the phenotype, which may range from benign mood swings to chronic psychosis, and by apparently nonmendelian modes of transmission. Early reports of linkage to chromosomal loci have fallen into doubt; however t...

Multiple biochemical correlates of manic-depressive illness.

Lithium, manic-depressive illness, and psychological test performance.

Lithium, manic-depressive illness, and psychological test performance For over 10 years patients responding to treatment at a lithium clinic' have been free from psychiatric symptoms. Little is known about the psychological performance of such patients, but a report,2 using the Minnesota Multiphasic Personality Inventory (MMPI), confirmed that lithium produces a response in depression. Clinical...

Association between the tryptophan hydroxylase gene and manic-depressive illness.

BACKGROUND Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide ...

State-dependent tardive dyskinesia in manic-depressive illness.

We report the occurrence of a drug-resistant tardive dyskinesia coexistent with Parkinsonism-like symptoms in a manic-depressive patient. The tardive dyskinesia completely disappeared during the manic phases and recurred after remission over the course of different mood-cycles.