Manganese superoxide dismutase from Thermus thermophilus
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چکیده
منابع مشابه
Structure-function in Escherichia coli iron superoxide dismutase: comparisons with the manganese enzyme from Thermus thermophilus.
The crystal structure of dimeric Fe(III) superoxide dismutase (SOD) from Escherichia coli (3006 protein atoms, 2 irons, and 281 solvents) has been refined to an R of 0.184 using all observed data between 40.0 and 1.85 A (34,879 reflections). Features of this structure are compared with the refined structure of MnSOD from Thermus thermophilus. The coordination geometry at the Fe site is distorte...
متن کاملManganese superoxide dismutase from Thermus thermophilus. A structural model refined at 1.8 A resolution.
The structure of Mn(III) superoxide dismutase (Mn(III)SOD) from Thermus thermophilus, a tetramer of chains 203 residues in length, has been refined by restrained least-squares methods. The R-factor [formula: see text] for the 54,056 unique reflections measured between 10.0 and 1.8 A (96% of all possible reflections) is 0.176 for a model comprising the protein dimer and 180 bound solvents, the a...
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The tetrameric manganese superoxide dismutase from the extreme thermophile Thermus thermophilus HB8 crystallizes in space group P41212 (or its enantiomorph) with a = b = 147.5 A, c = 55.9 A. The diffraction patterns extent to 1.4 A, and the crystals are very resistant to decay induced by x-irradiation. Measurements of the crystal density in Ficoll gradients are consistent with an asymmetric uni...
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2 Introduction 3 Phylogenetic distribution and subcellular localization 3 Kinetics and mechanism 3 Molecular and chemical structure 5 Biological significance 8 Summary 9 References 10 Abstract Manganese superoxide dismutase (MnSOD) is the primary antioxidant enzyme that protects cells from oxidative stress by catalyzing dismutation of superoxide (O2 ) to hydrogen peroxide and oxygen in the mito...
متن کاملManganese Superoxide Dismutase: Guardian of the Heart
Submit Manuscript | http://medcraveonline.com MOJ Anat Physiol 2015, 1(2): 00006 was neonatal lethal. Due to background modifications, a small percentage of knockout mice showed dilated cardiomyopathy indicating increased vulnerability to oxidative injury in the cardiac myocytes [1]. Ikegami et al. [3] successfully generated tissuespecific MnSOD conditional knockout mice that would provide a us...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 1991
ISSN: 0022-2836
DOI: 10.1016/0022-2836(91)90569-r