Maneb adducts human peroxiredoxin 3 through thiol interactions
نویسندگان
چکیده
منابع مشابه
Thiol-reactivity of the fungicide maneb
Maneb (MB) is a manganese-containing ethylene bis-dithiocarbamate fungicide that is implicated as an environmental risk factor for Parkinson's disease, especially in combination with paraquat (PQ). Dithiocarbamates inhibit aldehyde dehydrogenases, but the relationship of this to the combined toxicity of MB + PQ is unclear because PQ is an oxidant and MB activates Nrf2 and increases cellular GSH...
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Epidemiological and in vivo studies have demonstrated that exposure to the pesticides paraquat (PQ) and maneb (MB) increase the risk of developing Parkinson's disease (PD) and cause dopaminergic cell loss, respectively. PQ is a well-recognized cause of oxidative toxicity; therefore, the purpose of this study was to determine if MB potentiates oxidative stress caused by PQ, thus providing a mech...
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The fungicide maneb is moderately soluble in water and undergoes hydrolysis. Its main products for hydrolysis and photolysis are EU, ETU, EBIS, and glycine. Microbial degradation of maneb represents a minor breakdown route. Aquatic metabolism yields the main products EBIS, ETU, and EU. A field dissipation study showed that maneb persisted in soil for one week when applied at 100 ppm. Maneb is a...
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ژورنال
عنوان ژورنال: Advances in Redox Research
سال: 2021
ISSN: 2667-1379
DOI: 10.1016/j.arres.2021.100008