Management of Severe Cerebral Venous Sinus Thrombosis After Post-vaccination Breakthrough COVID-19 Infection: A Case Report and Review of the Literature

Neurological manifestations related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may involve both peripheral and central nervous systems, including ischemic stroke cerebral venous sinus thrombosis (CVST). Hereby, we present an adult patient with post-vaccination breakthrough COVID-19 CVST, treated mechanical thrombectomy (MT). The manifested continuous tonic-clonic seizures, after insidious presentation headache left-sided weakness. SARS-CoV-2 testing was positive, despite full vaccination, using two approved mRNA platforms. Factor V Leiden polymorphism detected. initially managed anticoagulation, followed by MT a positive response. We provided comparison similar cases of COVID-19-associated CVST undergoing thrombectomy. High index suspicion prompt diagnosis are extremely important ensure immediate hospitalization therapy, since associated either vaccines or seems evolve rapidly high mortality rate. Even vascular complications. In addition, evaluation acquired hereditary thrombophilia be beneficial in phase, also without previous history thrombosis. Clinicians should start early medical treatment additionally consider the endovascular approach as optimistic choice refractory infection.