Management of GH treatment in adult GH deficiency
نویسندگان
چکیده
منابع مشابه
Growth hormone (GH) provocation tests and the response to GH treatment in GH deficiency.
OBJECTIVE To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD). SUBJECTS A total of 337 prepubertal GHD patients aged <10 years from the UK Pharmacia KIGS database (GH response to provocation test <20 mU/l). OUTCOME MEASURE Annual change in height standard deviation score (SDS) (revi...
متن کاملGH deficiency in adults.
Until the last decade, the diagnosis of GH deficiency (GHD) in adults was only considered as a marker of hypothalamo-pituitary disease. GHD in adults is now recognized as a specific clinical syndrome associated with a cluster of cardiovascular risk factors such as altered body composition with increased body fat, insulin resistance, adverse lipid profile, reduced physical performance, reduced b...
متن کاملImpact of GH replacement therapy on sleep in adult patients with GH deficiency of pituitary origin.
OBJECTIVES We previously reported that adult patients with GH deficiency (GHD) due to a confirmed or likely pituitary defect, compared with healthy controls individually matched for age, gender, and BMI, have more slow-wave sleep (SWS) and higher delta activity (a marker of SWS intensity). Here, we examined the impact of recombinant human GH (rhGH) therapy, compared with placebo, on objective s...
متن کاملImpact of Growth Hormone (GH) Deficiency and GH Replacement upon Thymus Function in Adult Patients
BACKGROUND Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and GH secretagogues reverse age-related changes in thymus cytoarchitecture and increase thymopoiesis. GH administration also enhances thymic mass and function in HIV-infected patients. Un...
متن کاملEfficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency.
CONTEXT Treatment of adult GH deficiency (AGHD) with daily injections of GH results in decreased adipose mass, increased lean body mass (LBM), increased bone mineral density, and improved quality of life. OBJECTIVE This study seeks to determine whether a depot preparation of GH given every 14 d would lead to comparable decreases in trunk adipose tissue as daily GH. DESIGN This open-label, r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Best Practice & Research Clinical Endocrinology & Metabolism
سال: 2017
ISSN: 1521-690X
DOI: 10.1016/j.beem.2017.03.001