Management and Outcomes of Femur Fractures in Patients with Duchenne Muscular Dystrophy

Background: Duchenne muscular dystrophy (DMD) is a severe, progressive X-linked recessive neuromuscular disorder characterized by muscle weakness and atrophy. Additionally, patients with DMD have significant reductions in bone mineral density compared to age-matched controls, which exacerbated concomitant steroid use. These findings dramatically increase fracture risk, may irreparably decrease functional status. The aim of this case series examine outcomes operative versus nonoperative management femur fractures patient population. Methods: An IRB-approved retrospective chart review was completed for treated at single institution between 2013-2022. Patients were excluded incomplete documentation, treatment initiation an outside hospital, or diagnosis different dystrophy. Demographic variables, information, status, adverse events collected each patient. Descriptive statistics used summarize demographic outcome variables. Results: A total 10 11 included analysis. All male average age 12.7 years clinical follow-up 286 days. Five five underwent fixation (Group A) six B). In Group A, three short-distance ambulators prior injury, all regained similar status postoperatively. locked intramedullary nail. One B ambulator the remainder nonambulatory; primary wheelchair users final follow-up. There no as result either group. Conclusion: Nonoperative cast immobilization remains acceptable option nonambulatory those minimally-displaced not amenable surgical intervention. Surgical intervention recommended higher-functioning goal restoring ambulatory Regardless modality, should receive aggressive physical therapy directed early weight-bearing, range motion, mobilization preserve strength, mass, mobility.