Malignant progression of donor-engrafted clonal hematopoiesis in sibling recipients after stem cell transplantation
نویسندگان
چکیده
منابع مشابه
Osteoporosis after stem cell transplantation
Background Stem cell transplantation has become as a novel treatment for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. Improved survival of transplant recipients has raised awareness of post-transplant complications. One of these complications is transplant-related osteoporosis. Methods In this manuscript we review prevention methods for transplant-relat...
متن کاملClonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.
Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by somatic mutations in the blood of otherwise healthy adults. We hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for lymphoma, CHIP at the time of ASCT would be associated with an increased risk of myelodysplastic syndrome and acute myeloid leukemia, col...
متن کاملExcellent survival after sibling or unrelated donor stem cell transplantation for chronic granulomatous disease.
BACKGROUND Matched related donor (MRD) hematopoietic stem cell transplantation (HSCT) is a successful treatment for chronic granulomatous disease (CGD), but the safety and efficacy of HSCT from unrelated donors is less certain. OBJECTIVE We evaluated the outcomes and overall survival in patients with CGD after HSCT. METHODS We report the outcomes for 11 children undergoing HSCT from an MRD ...
متن کاملDonor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis.
Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence of the donor's CMV status in a large cohort of patients. A total of 7018 patien...
متن کاملDonor CMV serological status and outcome of CMV seropositive recipients after unrelated donor stem cell transplantation; An EBMT Megafile analysis
1. Dept of Hematology, Huddinge University Hospital, Stockholm, Sweden 2. Department of Medical Statistics, Leiden University Medical Centre, Leiden, the Netherlands 3. Department of Medicine, University Hospital, Tübingen, Germany 4. Department of Hematology, Ospedale San Martino, Genova , Italy 5. Department. of Haematology/Oncology, University of Leipzig. Leipzig, Germany 6. Department of. H...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2020
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2020003168