Male-sterile phenotype of the neurological mouse mutant weaver
نویسندگان
چکیده
منابع مشابه
Dopamine Deficiency in the Weaver Mutant Mouse1
The dopamine system in weaver mutant mice (BGCBA-AwmJ/A background) was studied. Dopamine was 27% lower in the olfactory tubercle, 77% lower in the frontal cortex, and 75% lower in the striatum of 6-month-old weaver mice compared to control mice of the same age. Norepinephrine and serotonin were not lower in these brain areas. Tyrosine hydroxylase activity in the striatum was measured with a ra...
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متن کاملFunctional Analysis of the weaver Mutant GIRK2 K+ Channel and Rescue of weaver Granule Cells
In the neurological mutant mouse weaver, granule cell precursors proliferate normally in the external germinal layer of the cerebellar cortex, but fail to differentiate. Granule neurons purified from weaver cerebella have greatly reduced G protein-activated inwardly rectifying K+ currents; instead, they display a constitutive Na+ conductance. Expression of the weaver GIRK2 channel in oocytes co...
متن کاملCerebellar Alterations in the Weaver Mouse
The fine structure of the cerebellum of weaver mouse was examined and the paucity of granule cells and their axons, the parallel fibers, was confirmed. Unexpectedly, however, the dendritic spines of the Purkinje cells which, in normal animals, are the postsynaptic mates of the parallel fibers, were present. Furthermore, their essential morphology and their staining reactions were indistinguisha...
متن کاملWeaver mutant mouse cerebellum: defective neuronal migration secondary to abnormality of Bergmann glia.
Previous work showed that in cerebella of mice homozygous for the autosomal mutation weaver, wv, most postmitotic granule cell neurons die during the first 2 weeks after birth close to their site of genesis in the external granular layer. Analysis of the less severely affected heterozygotes by electron microscopy and autoradiography indicates that granule cell death occurs several days after ce...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1994
ISSN: 1058-8388
DOI: 10.1002/aja.1002000104