منابع مشابه
Making sense of transcribing chromatin
Eukaryotic cells package their genomes into a nucleoprotein form called chromatin. The basic unit of chromatin is the nucleosome, formed by the wrapping of ∼147bp of DNA around an octameric complex of core histones. Advances in genomic technologies have enabled the locations of nucleosomes to be mapped across genomes. This has revealed a striking organisation with respect to transcribed genes i...
متن کاملVisualization and analysis of unfolded nucleosomes associated with transcribing chromatin.
We have characterized the structure of transcriptionally active nucleosome subunits using electron spectroscopic imaging. Individual nucleosomes were analyzed in terms of total mass, DNA and protein content, while the ensemble of images of active nucleosomes was used to calculate a three-dimensional reconstruction. Transcriptionally active nucleosomes were separated from inactive nucleosomes by...
متن کاملReplicating and transcribing on twisted roads of chromatin.
Chromatin, a complex of DNA and proteins in the eukaryotic cell nucleus governs various cellular processes including DNA replication, DNA repair and transcription. Chromatin architecture and dynamics dictates the timing of cellular events by regulating proteins' accessibility to DNA as well as by acting as a scaffold for protein-protein interactions. Nucleosome, the basic unit of chromatin cons...
متن کاملThe Creation of Necessity: Making Sense of Cartesian Modality
دکارت در نوشته‌های کلامی خود، دو فرضیه‌ی گیج‌کنندۀ به هم پیوسته را به پیش می‌برد: فرضیۀ1) خداوند آزادانه حقایق ازلی را می‌آفریند (یعنی آموزۀ خلقت)؛ فرضیۀ2) حقایق ازلی بالضروره صادقاند. بنا به فرضیۀ نخست، خداوند آزادانه برمی‌گزیند که کدام قضایا ضروری باشد، کدام محتمل و کدام ممکن. اما آموزۀ خلقت دکارت قبول فرضیۀ دوم را دشوار می‌سازد، زیرا مستلزم آن است که خداوند می‌توانسته است ــ با ایجاد مج...
متن کاملMaking sense of electrical sense in crayfish.
The five sensory modalities of humans are also found in a wide range of invertebrates. Other vertebrates have evolved additional special senses, such as the magnetic sense, which are also found in some invertebrates. However, there remain a few sensory abilities that curiously appear to be found in either vertebrates or invertebrates, but not both. For example, electrosensitivity - the ability ...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2012
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2012.02.003