Making it personal: translational bioinformatics

Making it personal: translational bioinformatics

One of the most exciting research areas in Translational Bioinformatics 2 is related to the redefinition of fundamental notions of what constitutes a ‘disease.’ Nosology, the systematic classification of diseases, dates back to Carl Linnaeus, with the Genera Morborum Today, the improvement in our abilities to make molecular measurements related to health and disease has largely driven the revol...

Making it personal; mentoring future family docs.

Biomarkers for rheumatoid arthritis: making it personal.

Effective treatment of rheumatoid arthritis (RA) has been hampered by the heterogeneity of the disease. Although early intervention can result in disease remission, it requires early diagnosis - and current diagnostic tests are not sufficiently accurate or sensitive in the early stages of RA. As a result, RA is typically diagnosed only once damage to the joints has already begun, a time at whic...

What is translational bioinformatics?

In 2001, the Human Genome Project successfully completed the first full human genome sequence (Lander et al., 2001; Venter et al., 2001). With the advent of next generation sequencing (NGS) platforms, what took over 3 billion dollars and more than 10 years to complete can nowbedone for as little as $1000 and in only a fewdays. The application of NGS has enabled for the interrogation of the huma...

Translational Bioinformatics 101

The following sections are included:Workshop FocusWorkshop AgendaWorkshop ContributionsReferences.