منابع مشابه
Major sperm protein
What is it? Major sperm protein, commonly referred to as MSP, is the centerpiece of the motility machinery that propels the crawling movement of nematode sperm. MSP was originally identified in Caenorhabditis elegans, but has since been found in sperm from several other species of nematode. The name derives from the abundance and cellular specificity of the 14 kDa protein: MSP makes up 15–20% o...
متن کاملMajor Sperm Protein Genes from Globodera rostochiensis.
Three genes in the major sperm protein (MSP) gene family from the potato cyst nematode Globodera rostochiensis were cloned and sequenced. In contrast to the absence of introns in Caenorhabditis elegans MSP genes, these genes in G. rostochiensis contained a 57 nucleotide intron, with normal exon-intron boundaries, in the same relative location as the intron in Onchocerca volvulus. The MSP genes ...
متن کاملBiochemical mechanisms for regulating protrusion by nematode major sperm protein.
Crawling motion is ubiquitous in eukaryotic cells and contributes to important processes such as immune response and tumor growth. To crawl, a cell must adhere to the substrate, while protruding at the front and retracting at the rear. In most crawling cells protrusion is driven by highly regulated polymerization of the actin cytoskeleton, and much of the biochemical network for this process is...
متن کاملHydrostatic Pressure Shows That Lamellipodial Motility in Ascaris Sperm Requires Membrane-associated Major Sperm Protein Filament Nucleation and Elongation
Sperm from nematodes use a major sperm protein (MSP) cytoskeleton in place of an actin cytoskeleton to drive their ameboid locomotion. Motility is coupled to the assembly of MSP fibers near the leading edge of the pseudopod plasma membrane. This unique motility system has been reconstituted in vitro in cell-free extracts of sperm from Ascaris suum: inside-out vesicles derived from the plasma me...
متن کاملMajor regulatory mechanisms involved in sperm motility
The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosi...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2005
ISSN: 0960-9822
DOI: 10.1016/j.cub.2005.02.036