Major Genetic Determinants of Extended-Spectrum Β-Lactamase (ESBL), Carbapenemase, Fosfomycin and Colistin Resistance in Escherichia Coli from Intensive Care Units

Escherichia coli (E. coli) strains placed in predominant nosocomial bacteria intensive care units (ICUs), resulting severe drug-resistant infections. Non-susceptibility to β-lactams and last-line drugs such as Fosfomycin Colistin cause limited availability of infections eradication. The objective this study included the determination genes encoding extended-spectrum β-lactamase (ESBL), Carbapenemase, Colistin, resistance clinical isolates E. ICUs. A total 200 were identified from ICU settings. CTXM-1, SHV, IMP OXA-48 detected for β-lactamases using polymerase chain reaction (PCR) technique. fosA3 mcr-1 mcr-2 also against Colistin. CTX-M1, 60 (30%), 56 (28%), 28 (14%) 4 (8%) isolates. none had genes. Despite existence third-generation antibiotics Carbapenemase s, any More studies are needed follow last-resort antibiotics.