منابع مشابه
"Magic" Ionization Mass Spectrometry
The systematic study of the temperature and pressure dependence of matrix-assisted ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by some reviewers as either sleight of hand or the misinterpretation by an overzealous young scientist of results reported many years before and having little utility. The “magic” that we were attempting to report was that w...
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Common to all experiments in mass spectrometry is the creation of gas-phase ions. Electron impact (EI) ionization is a familiar method for creating ions from volatile gas-phase molecules (M). In EI ionization, fast-moving electrons remove an electron from the neutral molecule to create the odd-electron molecular ion M`Õ. Another common ionization method is chemical ionization (CI). Here, an ion...
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A method called nanotip ambient ionization mass spectrometry (NAIMS) is described, which applies high voltage between a tungsten nanotip and a metal plate to generate a plasma in which ionized analytes on the surface of the metal plate are directed to the inlet and analyzed by a mass spectrometer. The dependence of signal intensity is investigated as a function of the tip-to-plate distance, the...
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An electrostatic-spray ionization (ESTASI) method has been used for mass spectrometry (MS) analysis of samples deposited in or on an insulating substrate. The ionization is induced by a capacitive coupling between an electrode and the sample. In practice, a metallic electrode is placed close to but not in direct contact with the sample. Upon application of a high voltage pulse to the electrode,...
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LEVEL: INTERMEDIATE D iscovery, development, and commercialization of novel biologics frequently involve collaboration between two or more companies. In the context of these business relationships, transfer of technology from one institution to another is a crucial step that needs to be executed f lawlessly and rapidly. Follow-up activities usually include the development of productive, reliabl...
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ژورنال
عنوان ژورنال: Journal of The American Society for Mass Spectrometry
سال: 2015
ISSN: 1044-0305,1879-1123
DOI: 10.1007/s13361-015-1253-4