Macrophage‐Targeting Poly(lactide‐ <i>co</i> ‐glycolic acid) Nanoparticles Decorated with Multifunctional Brush Polymers

This study examines the potential of poly(lactic-co-glycolic acid) (PLGA) nanoparticles functionalized with poly(zwitterion)-mannose brushes to target macrophages. Uptake studies RAW 264.7 macrophages indicate that multiple mannose-binding sites in grafted facilitate interaction mannose receptor macrophages, resulting approximately four times higher cellular uptake than monolayer coatings. To test feasibility as long-circulating drug delivery vehicles, their multicomponent aggregation blood plasma is analyzed using nanoparticle tracking analysis and compared poly(ethylene glycol)-coated (PEGylated) particles, which are known reduce aggregation. There no significant difference behavior particles PEGylated control (≈760 aggregates per 105 particles). In addition, particle size compared, includes protein corona, after 0, 8, 15 h. Whereas there at longer time scales, overall brush-grafted ≈130 nm smaller shorter suggesting a corona. All these results suggest acid brush grafts may be excellent candidates for targeted