Macrophages sustain HIV replication in vivo independently of T cells
نویسندگان
چکیده
منابع مشابه
Macrophages sustain HIV replication in vivo independently of T cells.
Macrophages have long been considered to contribute to HIV infection of the CNS; however, a recent study has contradicted this early work and suggests that myeloid cells are not an in vivo source of virus production. Here, we addressed the role of macrophages in HIV infection by first analyzing monocytes isolated from viremic patients and patients undergoing antiretroviral treatment. We were un...
متن کاملRestriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers.
How HIV controllers (HICs) maintain undetectable viremia without therapy is unknown. The strong CD8(+) T-cell HIV suppressive capacity found in many, but not all, HICs may contribute to long-lasting viral control. However, other earlier defense mechanisms may be involved. Here, we examined intrinsic HIC cell resistance to HIV-1 infection. After in vitro challenge, monocyte-derived macrophages a...
متن کاملIMMUNOBIOLOGY Restriction of HIV-1 replication in macrophages and CD4 T cells from HIV controllers
1Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France; 2Assistance Publique–Hopiteux de Paris (AP-HP), Centre Hospitalier Universitaire (CHU) Necker-Enfants Malades, Laboratoire de Virologie, Paris, France; 3Inserm U1018, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; 4Inserm U1012, Le Kremlin-Bicêtre, France; 5AP-HP, Hôpital Bicêtre, Service de Médecine Interne et Mal...
متن کاملHIV-1 Infection of T Cells and Macrophages Are
The proline repeat motif (PxxP) of Nef is required for interaction with the SH3 domains of macrophage-specific Src kinase Hck. However, the implication of this interaction for viral replication and infectivity in macrophages and T lymphocytes remains unclear. Experiments in HIV-1 infected macrophages confirmed the presence of a Nef:Hck complex which was dependent on the Nef proline repeat motif...
متن کاملNaive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells.
Stimulation with antibodies to CD3 and CD28 coimmobilized on beads can be used to significantly expand T cells ex vivo. With CD4 T cells from HIV-infected patients, this expansion usually is accompanied by complete suppression of viral replication, presumed to be caused by down-regulation of the viral coreceptor CCR5 and up-regulation of CCR5 ligands. Here we show that this suppression occurs i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci84456