Macrophages in intestinal homeostasis and inflammation

Intestinal Macrophages in Homeostasis and Inflammation

As the intestinal mucosa is continuously exposed to numerous commensal bacteria, it is thought that the gut may possess innate and acquired immune system regulatory mechanisms to prevent excessive inflammatory responses against commensal bacteria. Macrophages are the major population of tissue-resident mononuclear phagocytes, and ISSN 1598-9100 http://dx.doi.org/10.5217/ir.2012.10.4.317 Intest ...

Macrophages in intestinal homeostasis and inflammation

The intestine contains the largest pool of macrophages in the body which are essential for maintaining mucosal homeostasis in the face of the microbiota and the constant need for epithelial renewal but are also important components of protective immunity and are involved in the pathology of inflammatory bowel disease (IBD). However, defining the biological roles of intestinal macrophages has be...

Mucosal Macrophages in Intestinal Homeostasis and Inflammation

Intestinal macrophages are essential for local homeostasis and in keeping a balance between commensal microbiota and the host. However, they also play essential roles in inflammation and protective immunity, when they change from peaceful regulators to powerful aggressors. As a result, activated macrophages are important targets for treatment of inflammatory bowel diseases such as Crohn's disea...

Inflammation and Intestinal Homeostasis-associated Genes in Colorectal Cancer

Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis

de la Motte CA. Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol 301: G945–G949, 2011. First published August 18, 2011; doi:10.1152/ajpgi.00063.2011.—The causes of fibrosis, or the inappropriate wound healing, that follows chronic intestinal inflammation are not well defined and likely involve the contributions of multiple...