Macrophage-mediated response to hypoxia in disease
نویسندگان
چکیده
منابع مشابه
Macrophage-mediated response to hypoxia in disease
Hypoxia plays a critical role in the pathobiology of various inflamed, diseased tissues, including malignant tumors, atherosclerotic plaques, myocardial infarcts, the synovia of rheumatoid arthritic joints, healing wounds, and sites of bacterial infection. These areas of hypoxia form when the blood supply is occluded and/or the oxygen supply is unable to keep pace with cell growth and/or infilt...
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Macrophages are ubiquitous in the stromal compartment of tissues under normal physiological conditions and the number of these cells increases markedly with the onset and progression of many pathological states. The mechanisms underlying this response are well described in such conditions as wound healing and malignant tumors, where tissue-specific signals enhance the extravasation of blood mon...
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ژورنال
عنوان ژورنال: Hypoxia
سال: 2014
ISSN: 2324-1128
DOI: 10.2147/hp.s49717