منابع مشابه
Resistance to macrolides and related antibiotics in Streptococcus pneumoniae.
Resistance to erythromycin in Streptococcus pneumoniae was first detected in 1967 in the United States and subsequently worldwide (11, 20). The corresponding mechanism was rapidly identified as ribosomal methylation, which had been primarily reported as being responsible for erythromycin resistance in staphylococci (44). Further spread of resistance was then noted in a few countries, such as Fr...
متن کاملInducible macrolides-lincosamides-streptogramin B resistance in Bacteroides species.
The first evidence is presented for the presence of inducible macrolides-lincosamides-streptogramin B resistance in Bacteroides species. Different macrolides induced clindamycin resistance in Bacteroides vulgatus RYC18F6, an erythromycin-resistant and clindamycin-susceptible strain. A study of 144 Bacteroides isolates indicated that erythromycin resistance was linked to diminished clindamycin s...
متن کاملMacrolides and bronchiectasis: clinical benefit with a resistance price.
J. Stuart Elborn, MD Michael M. Tunney, PhD BRONCHIECTASIS IS A COMMON CONDITION. ALTHOUGH the true prevalence is unknown, the prevalence in the United States has been estimated to range from 4 per 100 000 in young adults to nearly 300 per 100 000 in persons75yearsandolder.Althoughbronchiectasisisapathological description, it describes a group of conditions of somewhat diverse etiology that res...
متن کاملMutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to macrolides in M. hominis.
The mechanisms of intrinsic resistance of Mycoplasma hominis to 14- and 15-membered macrolides were investigated in comparison with those of M. pneumoniae, which is naturally susceptible to macrolides. Radiolabeled erythromycin was not accumulated by M. hominis PG21, but addition of an ABC transporter inhibitor increased the level of erythromycin uptake more than two times, suggesting the exist...
متن کاملPneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes.
The macrolides, lincosamides, ketolides, and streptogramin B agents (the MLKS(B) antimicrobial agents) have related chemical structures and share similar molecular targets on the 50S ribosomal subunit of Streptococcus pneumoniae. Mutations in rRNA or ribosomal proteins generate a variety of resistance phenotypes. The M phenotype of S. pneumoniae, which predominates in North America, affords low...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2007
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.061448