منابع مشابه
Unexplained macrocytosis in elderly patients.
One hundred and twenty-four patients over the age of 75 years were assessed for the cause of their macrocytosis (MCV > 95 fl). A definitive diagnosis was reached in 75/124 (60%) by non-invasive techniques. The remainder underwent a bone marrow biopsy yielding a definitive diagnosis in a further six patients who had an identifiable myelodysplastic syndrome (MDS). A high proportion of the remaind...
متن کاملSunitinib causes macrocytosis in patients with advanced renal cell carcinoma.
BACKGROUND Sunitinib is approved for treatment of advanced renal cell carcinoma (RCC). Based on a clinical observation that patients receiving sunitinib developed macrocytosis, we undertook a study to further define this observation. METHODS In a retrospective review of RCC patients treated at a single centre, data on treatment duration, hematology parameters, concomitant medications, vitamin...
متن کاملEvaluation of macrocytosis.
Macrocytosis, generally defined as a mean corpuscular volume greater than 100 fL, is frequently encountered when a complete blood count is performed. The most common etiologies are alcoholism, vitamin B12 and folate deficiencies, and medications. History and physical examination, vitamin B12 level, reticulocyte count, and a peripheral smear are helpful in delineating the underlying cause of mac...
متن کاملTyrosine kinase inhibitor-induced macrocytosis.
BACKGROUND The tyrosine kinase inhibitors (TKI) sunitinib and imatinib were shown to induce macrocytosis in patients with renal cell cancer (RCC) and gastrointestinal stromal tumors (GIST), presumably through inhibition of the c-KIT dependent signaling pathway of erythroid progenitor cells of the bone marrow. PATIENTS AND METHODS Hematology charts of patients with RCC, breast cancer (BC), GIS...
متن کاملMacrocytosis in Down's syndrome and during long-term anticonvulsant therapy.
In a group of non-anaemic mentally retarded patients a significant increase in mean red cell volume has been demonstrated in epileptic patients being treated with anticonvulsants. The possible sites of interference of anticonvulsants with folate activity in the body, and problems associated with folic acid supplements during anticonvulsant therapy, are discussed. During the survey it was confir...
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ژورنال
عنوان ژورنال: Age and Ageing
سال: 1997
ISSN: 0002-0729,1468-2834
DOI: 10.1093/ageing/26.3.237-a