Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus

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Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus.

BACKGROUND Sperm coating protein beta-defensin 126 (DEFB126) is adsorbed onto the entire surface of macaque sperm in the caudal epididymis and is retained on viable sperm collected from the cervix and the uterine lumen of mated female macaques. We investigated the role of sperm coating protein DEFB126 in cervical mucus penetration (CMP). METHODS Cervical mucus (CM) was collected from peri-ovu...

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Contraception Cervical Mucus Sperm Penetration in Women on Oral Contraception or with an Iud in Situ

Penetration of cervical mucus by spermatozoa was observed in cycling and infertile women, in women on sequential or combination oral contraceptive medication, and in women with an IUD in situ. _Sperm penetration of cervical mucus varied from women not using contraceptives and from infertile women, to patients taking sequential conception control pills. In cycling women penetration was low in th...

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Sperm counts in enzymatically liquefied cervical mucus: quantitative validation using donor cervical mucus.

The post-coital test evaluates the penetration of spermatozoa into cervical mucus; it relies on subjective measurements and therefore lacks precision. Enzymatic liquefaction of cervical mucus allows sperm concentration to be measured in post-coital test samples, but the reliability of such measurements is not known. Donor cervical mucus was used as a model to test the accuracy and sensitivity o...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2008

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/den276