M-currents and other potassium currents in bullfrog sympathetic neurones
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چکیده
منابع مشابه
Calcium currents in bullfrog sympathetic neurons. II. Inactivation
Calcium currents in bullfrog sympathetic neurons inactivate slowly and partially during depolarizations lasting 0.5-1 s. There is also a slower (minutes) inactivation process with a broad voltage dependence. An irreversible loss of current (rundown) is prominent with low concentrations of intracellular Ca2+ buffers, with either Ca2+ or Ba2+ as the charge carrier. The extent and rate of the more...
متن کاملCalcium currents in bullfrog sympathetic neurons. I. Activation kinetics and pharmacology
The calcium current of bullfrog sympathetic neurons activates and deactivates rapidly (tau less than 3 ms). For brief depolarizations, the current can be fit reasonably well by a Hodgkin-Huxley-type model with a single gating particle of charge +3. With 2 mM Ca2+ as the charge carrier, half-maximal activation occurs at approximately -5 mV, near the voltage where activation and deactivation are ...
متن کاملCalcium Currents in Bullfrog Sympathetic Neurons L Activation Kinetics and Pharmacology
The calcium current o f bullfrog sympathetic neurons activates and deactivates rapidly (7 < 3 ms). For brief depolarizations, the current can be fit reasonably well by a Hodgkin-Huxley-type model with a single gating particle o f charge + 3. With 2 mM Ca 2+ as the charge carrier, half-maximal activation occurs at ~ 5 mV, near the voltage where activation and deactivation are slowest. When extra...
متن کاملActivation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.
Retigabine [D-23129; N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester] is a novel anticonvulsant compound that is now in clinical phase II development. It has previously been shown to enhance currents generated by KCNQ2/3 K(+) channels when expressed in Chinese hamster ovary (CHO) cells (Main et al., 2000; Wickenden et al., 2000). In the present study, we have compared the a...
متن کاملVoltage clamp study of fast excitatory synaptic currents in bullfrog sympathetic ganglion cells
Excitatory postsynaptic currents (EPSCs) have been studied in voltage-clamped bullfrog sympathetic ganglion B cells. The EPSC was small, rose to a peak within 1-3 ms, and then decayed exponentially over most of its time-course. For 36 cells at --50 mV (21-23 degrees C), peak EPSC size was --6.5 +/- 3.5 nA (mean +/- SD), and the mean decay time constant tau was 5.3 +/- 0.9 ms. tau showed a small...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1982
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1982.sp014357