Lysosomes, cholesterol and atherosclerosis

Dietary cholesterol and atherosclerosis.

The perceived relationship between dietary cholesterol, plasma cholesterol and atherosclerosis is based on three lines of evidence: animal feeding studies, epidemiological surveys, and clinical trials. Over the past quarter century studies investigating the relationship between dietary cholesterol and atherosclerosis have raised questions regarding the contribution of dietary cholesterol to hea...

Hormones, cholesterol, and coronary atherosclerosis.

Arterial lysosomes and connective tissue in primate atherosclerosis and hypertension.

The cellular events that occur in the vessel wall consequent to changes in endothelial permeability result in the progression of vascular disease, particularly atherosclerosis. Female rhesus monkeys were fed an atherogenic diet or were made hypertensive for 6-8 months; and their vessels were then compared with vessels from control monkeys. Length-defined segments of coronary vessels, the thorac...

Serum cholesterol and atherosclerosis in man.

HUMAN atherosclerosis has frequently been shown to be associated with derangement of some of the serum lipids. They may well have a bearing on the progression of the atherosclerotic process in man, but to establish this relationship is difficult. Extensive work has been done on blood cholesterol level in clinically diagnosed cases of atherosclerosis. Cases of myocardial infarction and angina pe...

HDL cholesterol and protective factors in atherosclerosis.

A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholesterol transport, its effects on endothelial cells, and its antioxidant activity. ...