منابع مشابه
Ion Channels and Membrane Potential
Cells are demarcated by the cell membrane. The cell membrane is a lipid bilayer in which various protein molecules are embedded (see Figure 1). In all animal cells, there is a large difference in ionic concentration between inside and outside the cell (Table 1). Na concentration is higher outside the cell and the K concentration is higher inside the cell. Intracellular Ca concentration is kept ...
متن کاملCell Membrane and Ion Channels
Contents 1. Introduction 2. Experimental techniques 2.1. Ion concentrations 2.2. Whole-cell recording 2.3. Current clamp and voltage clamp 2.4. Voltage clamp experiments 2.5. Recording single channel activity 2.6. Rundown 2.7. Effect of intracellular calcium buffering 2.8. Heterogeneity of cardiac cells 2.9. Electrical pathway between cells 3. Modeling the cell membrane and ion channels 3.1. El...
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Lysosomal permeability to potassium ions is an important property of the organelle. Influence of the membrane physical state on the potassium ion permeability of isolated lysosomes was assessed by measuring the membrane potential with bis(3-propyl-5-oxoisoxazol-4-yl)pentamethine oxonol and monitoring the lysosomal proton leakage with p-nitrophenol. The membrane fluidity of lysosomes was modulat...
متن کاملIon transport through cell membrane channels
We discuss various models of ion transport through cell membrane channels. Recent experimental data shows that sizes of ion channels are compared to those of ions and that only few ions may be simultaneously in any single channel. Theoretical description of ion transport in such channels should therefore take into account interactions between ions and between ions and channel proteins. This is ...
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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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ژورنال
عنوان ژورنال: SCIENTIA SINICA Vitae
سال: 2017
ISSN: 1674-7232
DOI: 10.1360/n052016-00345