منابع مشابه
Lysosomal accumulation of intravenously administered hyaluronidase.
Rat tail tendon collagen fibrils disaggregated in the mild experimental conditions to sub-fibrillar structures. The smallest, most frequent (protofibrils) were of fairly constant thickness, 12-15 nm. They often arose from larger subfibrils ( > 25 nm) that were nevertheless much smaller than the parent fibril. The protofibrils retained a faint banding pattern. They were oriented helically. The 2...
متن کاملThe presence of lysosomal hyaluronidase in the rabbit iris.
Lysosomal hyaluronidase in the rabbit iris was studied by means of a sensitive assay method based on carbocyanine dye binding. The enzyme activity in the lysosomal extract was proportional to both the enzyme concentration and the incubation time. When the enzyme was heated, the enzyme activity was lost completely. When the lysosomal extract was used as an enzyme source, the enzyme activity was ...
متن کاملChemically Induced Hepatomas Lysosomal Hyaluronidase Activity in Normal Rat Liver and in
SUMMARY It has been demonstrated that solid hepatoma lysosomes lack hyaluronidase activity, whereas normal rat liver lyso somes contain a high level of this enzyme. This result was also found with lysosomes from an ascites hepatoma, Walker carcinoma 256, and virally transformed BHK cells. In contrast, 0-yV-acetylglucosaminidase activity was shown to be present in lysosomes from tumor cells, alt...
متن کاملLysosomal hyaluronidase activity in normal rat liver and in chemically induced hepatomas.
It has been demonstrated that solid hepatoma lysosomes lack hyaluronidase activity, whereas normal rat liver lyso somes contain a high level of this enzyme. This result was also found with lysosomes from an ascites hepatoma, Walker carcinoma 256, and virally transformed BHK cells. In contrast, 0-yV-acetylglucosaminidase activity was shown to be present in lysosomes from tumor cells, although it...
متن کاملInvolvement of Lysosomal Labilisation and Lysosomal/mitochondrial Cross-Talk in Diclofenac Induced Hepatotoxicity
In this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. Diclofenac liver cytotoxicity was associated with reactive oxygen species (ROS) formation and lipid peroxidation which were inhibited by antioxidants and ROS scavengers, fer...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97311-4