Lysophosphatidylcholines inhibit human eosinophil activation and suppress eosinophil migration in vivo

Eosinophil Survival and Activation Sulfonylureas Inhibit Cytokine-Induced

Th2 and eosinophil responses suppress inflammatory arthritis

Th2-eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection fro...

Proteomics of Eosinophil Activation

We recently identified and quantified >7,000 proteins in non-activated human peripheral blood eosinophils using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and described phosphoproteomic changes that accompany acute activation of eosinophils by interleukin-5 (IL5) (1). These data comprise a treasure trove of information about eosinophils. We illustrate the power of labe...

Cytokine-Regulated Eosinophil Migration in Inflammatory Disorders

Lampinen, M. 2000.Cytokine-regulated eosinophil migration in inflammatory disorders. Clinical and experimental studies. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 971. 60 pp. Uppsala. ISBN 91-554-4849-6. The accumulation of eosinophil granulocytes (EOS) at sites of inflammation is a common feature of asthma, allergic rhinitis an...

Ligand density modulates eosinophil signaling and migration.

Eosinophils are a major component of the inflammatory response in persistent airway inflammation in asthma. The factors that determine the retention of eosinophils in the airway remain poorly understood. Elevated levels of fibronectin have been observed in the airway of patients with asthma, and the levels correlate with eosinophil numbers. To determine if fibronectin density modulates eosinoph...