منابع مشابه
Chemokines and Viral Infections of the CNS
A critical factor in the host immune response to invading pathogens, such as viral infections, is the recruitment and infiltration of immune cells to infected tissues. Although the goal of the recruited leukocytes is to eliminate the invading pathogens, collateral tissue damage may be induced in the process, and, in certain circumstances, may pose a serious threat to the survival of the host. T...
متن کاملChemokines and chemokine receptors in CNS pathology.
Chemokines are small proin ̄ammatory cytokines which stimulate migration of in ̄ammatory cells in vitro and in vivo. They can be divided according to structure, function and gene localization into four different subfamilies. Chemokines have been ascribed diverse additional functions, including regulation of angiogenesis, control of cell proliferation and developmental tissue patterning. The suspi...
متن کاملThe Role of Chemokines during Viral Infection of the CNS
Viral infection of the central nervous system (CNS) poses unique challenges to the immune system with regards to controlling and eliminating the invading pathogen. These obstacles include the presence of a blood–brain barrier (BBB) that provides a physical and physiological barrier that is difficult for cells and molecules to cross, the absence of classic lymphatic drainage that may impair the ...
متن کاملChemokines in the balance: maintenance of homeostasis and protection at CNS barriers
In the adult central nervous system (CNS), chemokines and their receptors are involved in developmental, physiological and pathological processes. Although most lines of investigation focus on their ability to induce the migration of cells, recent studies indicate that chemokines also promote cellular interactions and activate signaling pathways that maintain CNS homeostatic functions. Many hom...
متن کاملThe C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). It affects more than two million people worldwide, mainly young adults, and may lead to progressive neurological disability. Chemokines and their receptors have been shown to play critical roles in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine disease mode...
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ژورنال
عنوان ژورنال: Journal of Neuroimmunology
سال: 2010
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2010.05.017